Answer:
Inbreeding and greater chance of passing deletereous mutations through generations
Explanation:
There are several reasons why small populations are more prone to genetic diseases. One of them is that in small populations there tends to be more inbreeding
, that is breeding between individuals are closely related. Inbreeding increase the chances of offspring being affected by deletereus homozygous genotypes.
On the other hand, the acquisition of a deleterious mutation in a small population is more likely to be spread in that small population than in a large population.
Answer:
B- Most of the glucose 6-phosphate enters the pentose phosphate pathway.
Explanation:
Since the cell requires much more ribose 5- phosphate than NADPH, then it would lead the glucose 6-phosphate down the oxidative phosphate pathway to create ribulose 5-phosphate, which can be isomerized to ribose 5-phosphate depending on the cell state.
Answer:
1. The difference between the normal hemoglobin protein DNA sequence and the sickle cell hemoglobin DNA sequence is a base to base shift, in this case adenine (GAG) to thymine (GTG).
2. The difference affects the amino acid sequence of the protein by replacing glutamic acid (Glu) with valine (Val).
Explanation:
In sickle cell anemia, a change in the DNA nucleotide sequence is observed, where adenine is substituted by thymine, whose expression is the change in the amino acid sequence of globine β, incorporating valine instead of glutamic acid. This represents a molecular mutation - point mutation - by subtitution, which corresponds to missense mutation.
<u>Normal hemoglobin protein in a RBC</u>
DNA CTG ACT CCT GAG GAG AAG TCT
Amino acids Leu Thr Pro Glu Glu Lys Ser
<u>Sickle cell hemoglobin protein in a RBC</u>
DNA CTG ACT CCT <em>GTG</em> GAG AAG TCT
Amino acids Leu Thr Pro <em>Val</em> Glu Lys Ser
When GAG is transcribed to mRNA, the CUC codon is obtained, which codes for glutamic acid. Thymine substitution causes the DNA sequence to change to GTG, which is transcribed as CAC, the codon that encodes the amino acid valine. The <u>change from glutamic acid to valine in β-globin causes an altered hemoglobin, giving the abnormal erythrocytes observed in sickle cell disease</u>.
If your decreasing the size of something spinning your also decreasing the amount it spins so it would be spinning slower !