Disruption of axonal transport would be a good target for his drug.
<h3>What is disruption of axonal transport?</h3>
- Axonal transport defects are among the early molecular events leading to neurodegeneration in mouse models of amyotrophic lateral sclerosis (ALS).
- Gene expression profiles indicate that dynactin-1 mRNA is downregulated in degenerating spinal motor neurons of autopsied patients with sporadic ALS.
- Disruption of axonal transport also underlies the pathogenesis of spinal muscular atrophy and hereditary spastic paraplegias.
- The neurotoxin β,β′-iminodipropionitrile (IDPN) selectively disrupts slow axonal transport without affecting fast anterograde or retrograde axonal transport.
- Impairment of slow axonal transport causes a proximal accumulation of neurofilaments.
- Because neurofilaments regulate axonal diameter, this accumulation leads to a marked swelling of the axon.
- Acrylamide causes decreased axonal transport, also causing proximal accumulations of neurofilaments and swelling.
To learn more about axonal transport,
brainly.com/question/10600853
#SPJ4
Answer:
Solar waves with wavelengths between 160 and 400 nanometers are known as ultraviolet rays and carry higher levels of energy than sunlight. Solar waves with wavelengths between 780 and 1,500 nanometers are known as infrared rays and carry lower levels of energy than sunlight.
The four bases in DNA are: adenine, thymine, cytosine, guanine.
In RNA, thymine gets replaced by uracil.
Purine is only a name for the two bases guanine and adenine.