c-Met is an oncogene that contributes to the development of certain cancers by triggering cell division and tumor growth. In a 2
009 article, Yan and colleagues found regions in the 3' untranslated region of c-Met mRNA complementary to microRNA-1/206. In addition, higher levels of microRNA-1/206 were associated with slower cell proliferation. What is a likely explanation for the inverse correlation between microRNA-1/206 and cell proliferation?
According to Yan and colleagues 2009 article, cells that were transfected with microRNA-1/206 showed cell cycle arrest at the G1 phase and showed an increase in apoptosis (programmed cell death) which is important for synthesis of mRNA and protein. These processes have a direct effect on cell proliferation by decreasing it.
