Marine debris is defined as any man-made solid material that goes into waterways either directly or indirectly. Eighty percent of the marine debris comes from the land-based sources. Examples of marine debris are soda cans, plastic bag, cigarette waste. Anything that ends up in a water body that has a potential in harming the marine life is a marine debris.
Its stabilising. Since the selection pressure is against the extremes which are the normal blood and the sickle cell anaemia.
I think the answer you are looking for is peer review.