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Answer:
C. The enzyme with mutation 1 has decreased affinity for pyridoxal phosphate, whereas the enzyme with mutation 2 has lost the ability to bind to the substrates.
Explanation:
A coenzyme is an organic cofactor that binds with an enzyme in order to initiate or aid the function of the enzyme. A coenzyme binds to the active site of the enzyme (where the reaction occurs), thereby triggering its activation by modifying protein structure during the reaction. Some examples of coenzymes include Coenzyme A and Adenosine triphosphate (ATP). Pyridoxal phosphate is a coenzyme (it is the active form of vitamin B6) that is required for the function of cystathionase. Moreover, cystathionase is an enzyme that enables cells the synthesis of cysteine from methionine (transsulfuration pathway). The binding of pyridoxal phosphate to the enzyme increases the binding affinity of the enzyme for the substrate, thereby influencing its activity. In this case, it is expected that mutation 1 reduces the binding affinity of the enzyme to the cofactor, and thereby the cofactor is required at a higher concentration to restore normal enzyme activity.
(1) A. (2) D. (3) B. (4) A. (5) B. (6) C. (7) B. (8) B. (9) B. (10) A.
Answer:
Secondary level of protein structure
Explanation:
The proteins are formed of the monomer units called amino acids which bond with each other via peptide bond and form a linear peptide structure called the primary level structure of the protein.
The proteins to perform several functions in a cell undergoes structural conformation and attain the helical form called alpha helix due to the involvement of alpha carbon in bond formation and a pleated sheet called beta-pleated sheet due to the involvement of beta carbon. These structures are known as a secondary level of protein structure.
Thus, a Secondary level of protein structure is the correct answer.
Answer:
The purine ring is built onto ribose-5-phosphate of PRPP for its de-novo nucleotide biosynthesis, while the ring structure of the pyrimidine bases are synthesized separately and then coupled to ribose-5-phosphate via the C-N glycosidic bond.
Explanation:
In the de novo synthesis of nucleotides, their metabolic precursors such as aminoacids, ribose-5-phosphate, CO₂ and NH₃ are used as starting materials.
In purine nucleotide synthesis, the ring structure is built up on ribose-5-phosphate of PRPP by addition of one or a few atoms one at a time starting with the amino group donated by glutamine until the first intermediate inosinate is synthesized.
In pyrimidine ring synthesis, orotate is first synthesized from carbamoyl phosphate and aspartate, and then is attached to ribose-5-phosphate of PRPP, before it is then converted to the common pyrimidine nucleotides starting from uridylate.