Tissue damage activates nociceptors or pain receptors in the skin. A signal is sent to the peripheral nerve to the spinal cord where neurotransmitters or chemical messengers are released. It activates other nerves to pass signal to the brain. The signals are relayed to the somatosensory cortex for sensation, frontal cortex for thinking and limbic system for emotional response.
This is because the seven-sugar intermediate is synthesized by sugar addition to cytosolic-facing dolichol phosphate. The intermediate is flipped from the cytosol face of the ER membrane to the the luminal face. Additionally, the sugar additions then occur within the lumen of the ER. The short forms of the intermediate are on the wrong side of the membrane to add to nascent polypeptides within the ER lumen. Incomplete adductants within the ER lumen are located appropriately to N-glycosylate nascent polypeptide.
Antibiotics are designed to target only the cells that are harmful to the human body
Answer:
Aspirin works by inhibiting the production of prostaglandins. Aspirin inhibits the formation of prostaglandins by combining with the COX enzymes. Prostaglandins function as messenger molecules to monitor different physiological procedures in distinct regions of the body. One of the prime activities of prostaglandins is to stimulate inflammation and pain.
Prostaglandins are also the essential controller of platelet aggregation. By changing the COX enzymes inside the platelets, aspirin makes platelets to lose the stickiness, which is required to instigate clotting of blood.
There are two forms of cyclooxygenase, that is, COX-1 and COX-2. COX-1 generates prostaglandins and COX-2 mediates pain and swelling in response to tissue injury. Aspirin prevents both COX-1 and COX-2 functioning, while COX-2 is the therapeutic target of the drug.
However, it is the association of aspirin with COX-1 in the gastrointestinal tract, which results in the unwanted side effects of the drug. COX-1 is required to sustain a thick lining of the stomach. As aspirin inhibits the COX-1 enzyme, thus, the continuous use of the drug can result in the thinning of mucus, which safeguards the stomach from gastric juices.
In such cases, stomach bleeding, ulcers, and in certain situations perforation of the stomach can take place. Therefore, aspirin exhibits both bad and good effects.
