Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
99201 requires 3 components, a problem focused history, a problems focus examination and a straight forward medical decision.
Answer:
E78
Explanation:
The 2019 ICD 10 CM expanded the E78.4 code (other lipidemia) to 78.41 elevated lipoprotein and 78.49 other hyperlipidemia.
Answer:
Option (d).
Explanation:
Sales presentation is mainly done to sell any products to the customers. The sales man and woman should provide each and every detail to the customer and should convince them to buy their products.
As both Mr. and Mrs. Nunez wants to enroll. The signs of both the partner are required on the legal form. Mr. Nunez can only sign on his behalf and he needs to wake up the Mrs. Nunez to sign on the legal documents of the paper.
Thus, the correct answer is option (d).
A women should drink 2.7 liters of water every day which is nearly 11.5 cups.
What is adequate intake (AI)?
when there is insufficient information to compute an average need, a dietary suggestion is utilized. An adequate intake is the typical daily nutrient intake of a healthy population that is thought to be sufficient for the population's needs.
A person's appropriate intake (AI) of water is determined by looking at how much water they typically drink.
Women 11.5 cups or 2.7 liters every day
Men 3.7 liters every day, or 15.5 cups.
Drinking water and the water found in meals are both included in the AI (about 20 percent of AI).
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