An example of a false negative is taking an HIV test and having the test come back negative to say the patient is clean, but in reality they have HIV. Another example of a false negative is a woman taking a pregnancy test saying "not pregnant" (i.e. test is negative), but she actually is pregnant. Between those two examples, it is better to have a false negative pregnancy test because it is non life threatening.
A false positive example would be getting bad news you have cancer, when you actually don't have cancer. Another false positive example is a test saying you have a cold virus, when in actuality you don't. The first example mentioned would have the patient likely go through intense chemo treatments which would greatly affect their livelihood. The second example is a more harmless false positive as it would involve at most a flu shot if anything.
Protein-protein interactions within the CARMA1-BCL10-MALT1 complex:
- The T-cell receptor and B-cell receptor-dependent NF-B induction and lymphocyte activation are mediated by the CBM complex, which is made up of the proteins CARMA1, BCL10, and MALT1.
- Each of the proto-oncoproteins CARMA1, BCL10, and MALT1 is a somatic gain-of-function mutation or chromosomal translocation, and dysregulation of CBM signaling is a characteristic of numerous lymphoid malignancies, including Activated B-cell Diffuse Large B-cell Lymphoma.
- Moreover, a number of immunological dysregulation diseases have been linked to both gain- and loss-of-function germline mutations in CBM complex proteins.
- Over the past ten years, careful examination of the interactions of CBM components has yielded a wealth of detailed structural knowledge.
- Here, we discuss important discoveries about the molecular nature of these protein-protein interactions that have helped the research develop a detailed understanding of how these proteins come together to form high-order filamentous CBM complexes.
- Approaches to therapeutic suppression of the CBM complex have thus far centered on obstructing MALT1 protease activity in order to treat lymphoid malignancy and/or autoimmunity.
- The structural effects of MALT1 protease inhibitors on significant protein-protein interactions are also reviewed in detail.
To learn more about protein-protein interaction visit:
brainly.com/question/14573382
#SPJ4
Answer:
Predator-prey relations are an important driving force to improve the fitness of both predator and prey. In terms of evolution, the predator-prey relationship continues to be beneficial in forcing both species to adapt to ensure that they feed without becoming a meal for another predator.
Explanation:
Hope this helps!!
Answer:
A cinder cone is a short, steep volcano that blasts out
pyroclastic material.
Explanation:
A cinder cone is basically a sharp conical hill which consist of a loose pyroclastic fragments that are being formed on the sides on volcanic vent.
Simply think of a steep volcano and how it acts when it blats out, this is what cinder cone is. When the lava is blown out in a very violent manner, it breaks in to very small particles that can be addressed as cinder. Almost all the cinder cones are made up of pyroclastic substance.
Dry hands and peeling skin
