Answer:
the answer to the question is c
Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
Answer:
About a pound
Explanation:
7 days * 500 cal / day = 3500 cal <==== about a pound of fat cals
Answer:
Try not to go on their social media as much and you shouldn't have to worry about it. If you still keep doing it just keep away from the fried requests and try not to message their friends.
Explanation:
Answer:
tunica intima (inner layer)
Explanation:
Walls of veins is composed of three layers, which are:
- A. Outer layer (tunica adventitia) is of connective tissue with the collagen fibers.
- B. Middle layer (tunica media) is of smooth muscle which are arranged circularly and the elastic fibers.
- <u>C.Inner layer (tunica intima) which consists of specialized simple squamous epithelium which are also known endothelium which lines all the blood vessels and endocardium of heart.</u>
