In the heart, the valves are located between atria and ventricles and between ventricles and arteries (option D).
<h3>What are valves in the heart?</h3>
Valves are membranous partitions which permit the passage of the contents of a vessel or cavity in one direction, but stop or control the flow in the opposite direction.
Valves in the heart enforce a one-way blood flow through the heart and separate atria from ventricles, and ventricles from the large arteries that leave them.
The four valves in the heart and their location is as follows:
- tricuspid valve: located between the right atrium and the right ventricle
- pulmonary valve: located between the right ventricle and the pulmonary artery
- mitral valve: located between the left atrium and the left ventricle
- aortic valve: located between the left ventricle and the aorta.
The valves between the atria and ventricles are called atrioventricular valves or cuspid valves while those at the bases of the large vessels leaving the ventricles are called semilunar valves.
Therefore, it can be said that the valves of the heart are located between atria and ventricles and between ventricles and arteries.
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The answer is B because:
Cell walls are made of cellulose and proteins (hence II).
Animal cells don't have cell walls (only cell membrane) but plant cells do so IV
They must be semipermeable since materials for example carbon dioxide and water for photosynthesis have to go into the cell <em>some</em> way.
Lipids don't store genetic informations so the answer is 2
they absorb liposoluble vitamins they offer insulation/cushioning they store energy
This is because direct power has no pulsation (waveform characteristic) that is significant in electromagnetic induction. The gradual increase and decrease of power, at a given frequency, in indirect power is significant in electromagnetic induction. This enables transformers to induce electricity into the secondary coil, from the primary coil, at the core of the transformer.Transformers transform electric power by increasing or decreasing the voltage and current of electricity.
Answer:
Exosomes as Therapeutic Target
Given the fact that elevated exosome levels are often correlated with greater severity of different types of cancer, reducing circulating exosomes to normal levels is one of therapeutic strategies to increase treatment efficacy. There are different approaches to modulate exosome production: 1) Inhibition of exosome formation: inhibit crucial proteins involved in exosome formation pathway; 2) Inhibition of exosome release: inhibit important regulators of exosome release process, increased intracellular Ca2+, change cellular microenvironmental pH; 3) Inhibition of exosome uptake: add proteinase for surface proteins on exosomes may serve as receptors for uptake pathways. In addition to control exosomes production, removal of exosomes from the entire circulatory system might be a novel strategy for cancer treatment.
Exosomes could also be used as cancer immunotherapy becasue tumor-derived exosomes carry antigens that is a great source of specific stimulus for the immune response against tumors. Both tumor-derived and dendritic cell-derived exosomes have showed capability to stimulate tumor antigen-specific responses in experimental animal models and human clinical trials.
Exosomes as Targeted Drug Delivery Vehicles
Exosomes became one of the most common methods applied in drug delivery system because of several advantages they have. Firstly, exosomes normally have a small size 40-100 nm, which is more homogenous compared to other microvesicles. This will lead them to evade rapid clearance by the mononuclear phagocyte and enhances passage through fenestrations in the vessel wall. Secondly, due to their endogenous origin, they are less toxic for and better tolerated by the immune system. It facilitates them to avoid causing side effects that normally occur with synthetic nanoparticles. Additionally, the specific ligand or protein expressed on the exosome surface increases efficiency of cargo into the cytosol of the target cell, and therefore fewer off-target effects. Exosomes are generally found most useful as a drug delivery medium in cancer therapy, anti-inflammation and gene interference therapy such as transferring of miRNA.
There are different kinds of cargos encapsulated by exosomes, especially like siRNA or miRNA. The delivery of RNA is attracting because they are rapid degradation in cell circulation and have the limitation in passing through the membrane and in cellular uptake. Chemotherapeutics loaded into exosomes is also used for cancer therapy such as doxorubicin. In principle, there are four key components to achieve correct functionality and efficacy during exosomes drug delivery:1) Choosing the donor cell type to produce drug-carrying exosomes; 2) Using correspond methods to encapsulate the exosomes cargo; 3) Enhancing the specificity of cargo delivery by targeting peptides on the surface of the exosomes; 4) Administrating exosomes to target the area of disease.
Explanation:
https://www.creative-biostructure.com/exosome-applications-652.htm
