Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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Answer:
<em>The correct option is B) 5-10%</em>
Explanation:
We have seen and depicted various scenarios where we see how different changes arise and dominate the world. Social scientists suggest that as low as 5-10% people of a population are enough to bring about a change because people tend to copy what others are doing. Same goes for countries of the world. Each new popular technique which is learnt by one country tends to become popular and learnt by other countries. For example, the usage of a social app starts with a few members of a population using it and with time it becomes popular in the whole world.
Geology is a branch of natural science that studies rocks, how they form, etc.
This field of study enabled us to know the age of Earth, the different layers that make up earth amongst many other things.
Hope it helped,
BioTeacher101
(If you have any questions, feel free to ask them in the comments)
The answer is D. Carbon cycle
