Cyclins
are the chemicals that regulate the cell cycle. Cyclins work by regulating the timing
of the cell cycle in eukaryotic cell. Cyclins activates cyclin dependent
kinases (CDKs) (an enzyme that works by adding <span>negatively charged phosphate groups to other
molecules in a process called phosphorylation) by binding to it to form a cyclin-Cdk
complex. This complex then functions by acting as a signal to the cell to move
to the next cell cycle phase. At the end of the event, the cyclin is degraded, Cdk
is deactivated, therefore signaling exit from a specific phase.</span>
Answer: If a mutation occurred in Silencer of Death Domain (SODD) that prohibited its interaction with the DD of TNF receptor, the TNF receptor would evoke its response by binding to a transmembrane receptor, TNFR1.
Explanation: Binding to TNFR1 inhibits the recruitment of cytoplasmic signaling proteins to TNFR1 to prevent recruitment of a number of protein (TRADD) or prevent spontaneous aggregation of the cytoplasmic death domains of TNFR1 molecules.
SODD mechanism is useful in preventing unwarranted TNFR1 activation in the process of apoptosis.
They are all the examples of organ system.