Julius Caesar, the Roman dictator, was assassinated by a group of senators on the Ides of March (15 March) of 44 BC during a meeting of the Senate at the Theatre of Pompey in Rome. The senators stabbed Caesar 23 times. The senators claimed to be acting over fears that Caesar's unprecedented concentration of power during his dictatorship was undermining the Roman Republic, and presented the deed as an act of tyrannicide. At least 60 senators were party to the conspiracy, led by Marcus Junius Brutus, Gaius Cassius Longinus and Decimus Junius Brutus. Despite the death of Caesar, the conspirators were unable to restore the institutions of the Republic. The ramifications of the assassination led to the Liberators' civil war and ultimately to the Principate period of the Roman Empire.
It's a prediction in the plot of the story. Example: "He knew that bad things were to come." This shows that there was a prediction of things to happen.
It details the origins of the infection in China, and its spread via human trafficking, refugees, and the organ trade. Governments of the world ignore it until a public outbreak occurs in a South African shantytown, leading to Israel unifying with Palestine and closing its borders.