I believe for a male its 26
Human monoclonal antibody (mAbs) are emerging in the field of cancer therapy and have become an increasing proportion of new drugs that are recently approved. Although there are some methods to obtain antigen-specific mAbs from human B cells, it is generally impossible to directly immunize human beings with antigens of interest. For example, for infectious agents, those approaches are largely restricted. To solve these obstacles, two main approaches have been developed; either by humanizing antigen-specific antibodies from small experimental animals (which is laborious due to the great genetic differences from humans) or rely on the in vitro selection of antigen-specific binders from human antibody repertoires. However, the human mAbs developed by these methods are usually with low affinity.
We are now coming up with a much better idea that is humanizing non-human primates mAbs instead of murine mAbs. Due to the close genetic relationship with humans, immunized NHPs have more potential to be isolated with high affinity antibody to human target than other experimental species, such as mouse, rat and rabbit. In addition, with appropriate method, NHP antibodies are much<span> easier to be humanized</span> without any loss of affinity compared to widely used murine antibodies.
Resource: http://www.creative-biolabs.com/High-Affi-TM-Human-Antibody-Discovery.html
Answer:
Alanine to lysine.
Explanation:
Mutation may be defined as the sudden, heritable change in the genome sequence of an organism. Two main types of mutation are chromosomal mutation and point mutation.
The mutation has occurred in which the arginine is replaced by alanine. The mutation that can restore to wild type is the conversion of alanine with lysine. Since both arginine and lysine are basic amino acids. They both shows almost similar function and the replacement of lysine with alanine shows the wild type activity.
Thus, the answer is alanine to lysine.
An individual's behavior can be influenced sociologically, psychologically and
physiologically by the arrangement of an interior environment. Dependent on functionality, co-working space etc of the room, a person may require more or less privacy which is related directly to productivity, social balance, personal happiness and other problematic or positive behavioral encounters.
