At the end of a sentence the modifier do not not require anycommas
because modifiers can only be used at the beginning or middle not in the ebd of a sentence
<span>An antagonist does not have to be a villain. Although
some use these words interchangeably, they have different meanings. An antagonist
simply disagrees to the viewpoints of the protagonist, while a villain destroys
a person or thing relevant to the plot of the story. Therefore, the key word
here is motive.</span>
a) The dog has a small patch on its leg.
b) There is too much salt in this soup.
c) Oil does not blend with water.
d) Consuming too much sugar can lead to health problems.
e) He has written a letter to his friend.