July is the warmest summer it has been proven by me and my fellow class mates.
* More than 40 proteins and glycoproteins involved in the complement system are synthesized by the liver, macrophages, epithelial cells, they are present in the blood in plasmatic form, membrane, some have an enzymatic activity, regulator or membrane receptorThese are elements of the humoral innate immune response, they fight infections, purify immune complexes and apoptotic bodies.
<span>There are indeed three ways to activate the complement:</span>
Classical pathway: Activated by Immunoglobulins in immune complexes, aggregated Immunoglobulins, DNA, CRP, apoptotic bodies .......it involves nine fractions, starting with C1, then C4, C2, C3, to form a classical C5 convertase, then, activation of C5, C6, C7, C8, C9.
Alternative pathway: activated by polysaccharides (bacterial endotoxin), vascular wall poor in sialic acid, aggregated IgE ...C3b like is the first component in the alternate channel cascade, it will create an amplification loop, and form an alternative C5 convertase.
Lecithin pathway: Activated by mannose, fucose (carbohydrate of microorganisms)The first component is the complex MBL / MASP1 / MASP2: "mannose-binding protein": works according to the same principle as the complex C1 of the classical way (MASP2 cleaves the C4 and the rest of the cascade is equivalent to that of the classical way).
the three ways have the same outcome: A C5 convertase (formed by one of the pathways) cleaves C5 into C5a and C5b: C5b is deposited far from other fractions on the antigenic surface. The fixation of C5b in the cell is followed by that of C6, C7, C8, and C9 (9 molecules of C9): formation of the membrane attack complex (MAC) ==> Death of the cell by osmotic shock
Answer:
Hypothalamus of human body system interact to perform temperature regulation along with nervous system and endocrine system.
Explanation:
Hypothamus is an important part of our lower brain that play a significant role in regulation of body temperature.
Hypothalamus works with nervous system along with the other parts of our body such as blood vessels,skin and sweat gland to maintain temperature homeostasis of human body.
When our body temperature rises at that time hypothalamus slows down the rate of metabolism of our body to restrict further increase in our body temperature and also dilates the blood vessels present beneath the skin so that body can liberate heat to the environment.
on the other hand when the body temperature decreases at that time hypothalamus increases the metabolic rate of our body to increase the body temperature and also the constrict the blood vessels present under the skin.