<span>Lafora disease is the most severe teenage-onset progressive epilepsy, a unique form of glycogenosis with perikaryal accumulation of an abnormal form of glycogen, and a neurodegenerative disorder exhibiting an unusual generalized organellar disintegration. The disease is caused by mutations of the EPM2A gene, which encodes two isoforms of the laforin protein tyrosine phosphatase, having alternate carboxyl termini, one localized in the cytoplasm (endoplasmic reticulum) and the other in the nucleus. To date, all documented disease mutations, including the knockout mouse model deletion, have been in the segment of the protein common to both isoforms. It is therefore not known whether dysfunction of the cytoplasmic, nuclear, or both isoforms leads to the disease. In the present work, we identify six novel mutations, one of which, c.950insT (Q319fs), is the first mutation specific to the cytoplasmic laforin isoform, implicating this isoform in disease pathogenesis. To confirm this mutation's deleterious effect on laforin, we studied the resultant protein's subcellular localization and function and show a drastic reduction in its phosphatase activity, despite maintenance of its location at the endoplasmic reticulum.
I got my information from </span>https://www.ncbi.nlm.nih.gov/pubmed/14722920
I’m pretty sure it’s d hope that helped
The correct answer is option A, that is, development often causes habitat fragmentation, which can threaten biodiversity.
Fragmentation is usually illustrated as a reduction in some of all the kinds of natural habitats in a landscape, and the differentiation of a landscape into smaller and more isolated segments. With the development of the fragmentation process, the ecological influences will modify.
Fragmentation can be a result of natural procedures like floods, fires, and volcanic activity, but it is more generally caused due to human activities like an increase in the number of roads, housing developments, shopping centers, and parking lots.
With the enhancement in human activities, the effect of fragmentation become more. Eventually, it results in the devastating influences on the local species, a complete modification to the landscape, and the loss of the region's wilderness heritage.
In eukariotes, cells that have a neculeus, the dna is found in the neculeus, not the cytoplasim so that is false... I dunno if that is what u were asking...
Answer:
B. Gently sloping mountain hardened magma in a pipe
Explanation:
A volcanic plateau is a plateau produced by volcanic activity. There are two main types: lava plateaus and pyroclastic plateaus.
