Water diffuses from the lumen into the interstitial space during the reabsorption of water in the proximal convoluted tubule due to an increase in the interstitium's osmolarity.
Reabsorption is the process by which water and solutes from the PCT are injected into the blood. From the proximal convoluted tubule, the solutes and water go to the interstitium before entering the peritubular capillaries. The majority of the solutes and 99 percent of the water filtered by the nephron must be reabsorbed; all of these chemicals were "absorbed" in the digestive tract. The peritubular and vasa recta capillaries return reabsorbed fluids and chemicals to the circulation.
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Answer:
The correct answer is: a.
Explanation:
- A Diploid organism possess two copies ( also called alleles) of each autosomal gene, of which one copy of the gene is obtained from one of its parents and the other copy from its other parent.
- During the process of replication, one of the alleles of the GTPase encoding gene undergoes a mis-sense mutation.
- A Mis-sense mutation can be defined as a non-synonymous mutation in which one of the nucleotide in the sequence of the gene gets altered such that it causes a change in the amino acid encoded by the codon (triplet nucleotide message encoding for a single amino acid) formed by the mutated nucleotide. A single amino acid change in the protein, if occurs in the functional site of the protein, can render a protein non-functional.
- Hence, the mis-sense mutation in one of the alleles encoding for the GTPase gene causes the resulting protein produced from the mutated allele to have drastically reduced function (1%).
- A heterozygous cell is one which has one copy of the normal allele and the other copy of the mutated allele of the GTPase encoding gene.
- As one copy of the normal GTPase allele is present in such an individual, it can produce the normal GTPase protein that can assist in the process of cell growth and division.
- Hence, the phenotype(expressed character) of the heterozygous cell will not be affected due to the mutation and it will be able to grow and divide normally.
Answer: This is a vertebrate animal with bilateral symmetry which has an endoskeleton. Most reproduce sexually through external fertilization.
Explanation:
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<h2>CRISPR/Cas9</h2>
Explanation:
CRISPR can be used to reintroduce dystrophin back into the KO mouse
- CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats and is used to for gene editing
- CRISPR/Cas-mediated genome editing has been shown to permanently correct DMD mutations and restore dystrophin function in mouse models
- Germline editing by injecting zygotes with CRISPR/Cas9 editing component was first done in mdx mice by correcting the mutated exon 23
- Postnatal editing of mdx mice was then achieved using recombinant adeno-associated virus to deliver CRISPR/Cas9 genome editing components and correct the dystrophin gene by skipping or deleting the mutated exon 23 in vivo
- Germline and postnatal CRISPR/Cas9 editing approaches both successfully restored dystrophin function in the mice and same technique can be used for KO mouse model
23 and for the female and for the male there are 46