Answer:
Option (a) and (d).
Explanation:
The breaks in DNA molecule may occur due to replication error and oxidizing agent. The double-stranded breaks in DNA can be corrected by Homologous end joining and non homologous end joining.
Homologous end joining is used to repair the DNA present in G2 nad S phases of the cell cycle. The homologous sequences of DNA is used to repair the DNA. Non homologous end joining occurs in the cell present at G0 and G1 phase of the cell cycle. The DNA broken ends are juxtaposed and later rejoin together by DNA ligase.
Thus, the correct answer is option (a) and (d).
The terms dominant and recessive describe the inheritance patterns of certain traits. ... For a recessive allele to produce a recessive phenotype, the individual must have two copies, one from each parent. An individual with one dominant and one recessive allele for a gene will have the dominant phenotype.
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Answer:
It has incomparable advantages over other gene editing tools.
Explanation:
For example, the CRISPR-Cas9 system has more target sites than ZFNs and TALENs, and Cas9 has many variants that can be used in a variety of studies. Moreover, the system is extremely easy to use and can be executed in almost any laboratory.
The most important advantages of CRISPR/Cas9 over other genome editing technologies is its simplicity and efficiency. Since it can be applied directly in embryo, CRISPR/Cas9 reduces the time required to modify target genes compared to gene targeting technologies based on the use of embryonic stem (ES) cells.
Disadvantages of CRISPR technology: CRISPR-Cas9 off-target; The effect of off-target can alter the function of a gene and may result in genomic instability, hindering it prospective and application in clinical procedure.
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