What? Can you explain your question please?
1) Brain Cancer. ...
2) Increases stress level. ...
3) Weakens immune system. ...
4) Chronic pain. ...
5) Eye/ vision problems. ...
6) Hinders sleep. ...
7) Germs. ...
8) Hampers your thinking process.
Macbeth drugged the guards with wine, which led to her stabbing Duncan. Afterwards she decides to frame the guards.
hope this helps