<span>Lafora disease is the most severe teenage-onset progressive epilepsy, a unique form of glycogenosis with perikaryal accumulation of an abnormal form of glycogen, and a neurodegenerative disorder exhibiting an unusual generalized organellar disintegration. The disease is caused by mutations of the EPM2A gene, which encodes two isoforms of the laforin protein tyrosine phosphatase, having alternate carboxyl termini, one localized in the cytoplasm (endoplasmic reticulum) and the other in the nucleus. To date, all documented disease mutations, including the knockout mouse model deletion, have been in the segment of the protein common to both isoforms. It is therefore not known whether dysfunction of the cytoplasmic, nuclear, or both isoforms leads to the disease. In the present work, we identify six novel mutations, one of which, c.950insT (Q319fs), is the first mutation specific to the cytoplasmic laforin isoform, implicating this isoform in disease pathogenesis. To confirm this mutation's deleterious effect on laforin, we studied the resultant protein's subcellular localization and function and show a drastic reduction in its phosphatase activity, despite maintenance of its location at the endoplasmic reticulum.
I got my information from </span>https://www.ncbi.nlm.nih.gov/pubmed/14722920
Answer for question 1- B (eliminate all plant life)
Answer for question 3- A (Direct energy from the Sun)
(i’m not entirely sure what the answer is to question 2 and i do apologies if any of this incorrect)
Answer:
Ulna
Explanation:
The humerus is the long bone in the upper arm. It is located between the elbow joint and the shoulder. At the elbow, it connects primarily to the ulna.
There's tropism and stimulus, for starters. Gravity, light, and touch can all be used as stimuli. So it is debatable... If the plant is reaching upwards towards a window that is above it... It would then be light, and the plant's response would be to reach upward.
Hope this helps and if it does, don't be afraid to give my answer a "Thanks" and maybe a Brainliest?
