Hormones or paracrines that inhibit gastric secretion include <u>secretin
</u>.
Explanation:
Hormones pass into the blood that waters the digestive system, go to the heart, circulate through the arteries and return to the digestive system, where they stimulate the production of digestive juices. The hormones that control digestion are gastrin, secretin and cholecystokinin. Secretin is stimulated by intestinal acid at the duodenal level. Its effect inhibits gastric acid secretion, prostaglandin secretion and via somatostatin release. It decreases gastric emptying and stimulates bile and pancreatic bicarbonate secretion.
Gastric secretions are triggered when there is food in the stomach or in anticipation of food. The control and regulation of these secretions is important to prevent disease conditions such as peptic ulcerations and reflux diseases which occur as a result of excess acid in the stomach.
The main inhibitor of gastric secretions is the hormone somatostatin. It acts through the SSTR2 receptors to inhibit the secretion of hydrochloric acid, histamine and gastrin.
Other agents that indirectly inhibit gastric secretions through the stimulation of somatostatin include;
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