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Considering people who suffer from diabetes can have issues and need help with circumventing the difficulties this disease can pose for them, it's very possible that other people (who are part of the support structure/inner social group of the person who's suffering from it) would need to help him or her with his diabetes issues.
This answer explains how other people might be affected by someone having diabetes in their particular social group. I hope this was what you were interested in, your question seemed to ask this.
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the answer is changes gradually
The answer for this will be C an integration of organ systems this is because the endocrine system also works with the nervous system and immune system etc
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are you nice girls or not