Long-term potentiation (LTP) is considered a cellular correlate of learning and memory. The presence of G protein-activated inwardly rectifying K(+) (GIRK) channels near excitatory synapses on dendritic spines suggests their possible involvement in synaptic plasticity. However, whether activity-dependent regulation of channels affects excitatory synaptic plasticity is unknown. In a companion article we have reported activity-dependent regulation of GIRK channel density in cultured hippocampal neurons that requires activity oF receptors (NMDAR) and protein phosphatase-1 (PP1) and takes place within 15 min. In this study, we performed whole-cell recordings of cultured hippocampal neurons and found that NMDAR activation increases basal GIRK current and GIRK channel activation mediated by adenosine A(1) receptors, but not GABA(B) receptors. Given the similar involvement of NMDARs, adenosine receptors, and PP1 in depotentiation of LTP caused by low-frequency stimulation that immediately follows LTP-inducing high-frequency stimulation, we wondered whether NMDAR-induced increase in GIRK channel surface density and current may contribute to the molecular mechanisms underlying this specific depotentiation. Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity.
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D) take in nutrients because endocytosis is the process when a cell takes in food
Answer:
A biome is described as an area of the planet, which is classified on the basis of plants and animals living in that area. Soil, amount of light, temperature, and water are some of the important factors that determine what type of life exists in a biome.
The temperature, vegetation, and precipitation are the important characteristics of the biome.
Examples of biomes include tundra, desert etc.
Answer:
Microorganisms are very small, not visible with an eye, including bacteria, viruses, fungi, and parasites.
Even though som of microorganisms can make people ill, many of them are not harmful, all the contrary, they can help a human with digestion, protect him from infections and keep the health good.
Explanation:
You have bad microorganisms in the body, called pathogens. Pathogens can be very harmful and kill all the good cells in the host. That is why good microorganisms are important. They make colonies and protect the body from the development of pathogens that release toxins into the body.
Good microorganisms provide nutrition for the organism, they involve minerals, produce hormones and stop bad microorganisms enter the organism.
Answer:
Peristalsis is a series of wave-like muscle contractions that move food through the digestive tract. ... There, the food is churned into a liquid mixture called chyme that moves into the small intestine where peristalsis continues. Stretching out a piece of intestine will make it easier to see the wave-like motion