A more stringent definition is agamogenesis which is reproduction without the fusion of gametes<span>. Asexual reproduction is the primary form of reproduction for single-celled organisms such as the </span>archaebacteria<span>, eubacteria, and protists. Many plants and fungi reproduce asexually as well.</span>
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
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Answer:
Explanation:
An element only has <u>one</u> type of atom and cannot be broken down by chemical means.
Let's analyze the answer choices.
1. This has two types of atoms, so it cannot be an element. It has more than one type of atom.
2. This has two types of atoms that are bonded together. It cannot be an element because there is more than one type of atom and the bonds can be broken.
3. This has one type of atoms, so it is an element.
Therefore the best answer choice is 3.
Answer: the beetle is neither harmed nor helped by the mite.
Explanation:In this case, the mite benefits because it gains transportation from the beetle. If the beetle is neither harmed nor helped by the mite, then the relationship between the mite and the beetle would be an example of commercialism.