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Lamarckism, a theory of evolution based on the principle that physical changes in organisms during their lifetime—such as greater development of an organ or a part through increased use—could be transmitted to their offspring.
Lamarck believed that the stretching elongated the giraffe's neck, which became a useful characteristic and was passed onto future generations. This resulted in the length of the giraffe's neck increasing over time. It is now commonly accepted that Lamarck's ideas were wrong.
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If the cancer cell's DNA is sequenced than the anticipated results will be that the cytosines in or close to the promoter region will get methylated. It has been stated that in the cancer cells one allele of p53 is mutated and the other allele, however, of exhibiting an intact promoter, does not express the protein.
Thus, it shows that the expression in the other allele gets suppressed by methylation rather than by mutation. Methylation generally takes place in CpG islands in or close to the promoter region and therefore inhibits transcription.