When atoms in a covalent bond share electrons unequally (one atoms pulls more than the other), the bond is said to be a polar bond is formed when electrons are unequally shared between two atoms. Polar covalent bonding occurs because one atom has a stronger affinity for electrons than the other (yet not enough to pull the electrons away completely and form an ion).
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Individuals with these mutations typically have familial hypercholesterolemia.
These genes provide information for the formation of the low-density lipoprotein receptor, a receptor that binds to low-density lipoproteins (LDLs). LDLs carry the cholesterol in the blood and regulate the amount of cholesterol in the circulation. Mutations to these genes either reduce the number of receptors or cause several disruptions to their function. This results in high blood cholesterol levels and in a higher risk for heart disease.
