SCA is a common monogenic blood disorder with potentially devastating consequences due to chronic and episodic disease; it has a massive impact on the health-care system and is linked to a significant reduction in life span.
We show that gene therapy with a lentivirus vector expressing γ-globin has the potential for a one-time cure and define the parameters required to cure the disease. We also show a preclinical in vivo method for determining the minimal amount of genetically corrected hematopoietic stem cells needed to correct disease, which is important in the design of clinical gene therapy trials.
The expression of the γ-globin gene in hematopoietic stem cells (HSCs) results in enough postnatal fetal hemoglobin (HbF) to correct sickle cell anemia (SCA) in the Berkeley "humanized" sickle mouse. We assessed critical parameters for correction after de-escalating the number of transduced HSCs in transplant recipients using reduced-intensity conditioning and varying gene transfer efficiency and vector copy number.
The minimal amount of HbF, F cells, HbF/F-cell, and gene-modified HSCs required for correcting the sickle phenotype was determined using a systematic quantification of functional and hematologic red blood cell (RBC) indices, organ pathology, and life span.
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Answer:
The arteries (red) carry oxygen and nutrients away from your heart, to your body's tissues. The veins (blue) take oxygen-poor blood back to the heart. Arteries begin with the aorta, the large artery leaving the heart. They carry oxygen-rich blood away from the heart to all of the body's tissues.
Explanation:
sorry if its wrong
The photosystem
This unit absorbs light energy for photosynthesis.
I am pretty much sure that C. Lyases is the answer.
Let me give some information about this.
Lyases are the main groups which show peculiarity in having more than several categorised groups having more enzymes than the other four.
Hydrolase does not fit this bill instead they contain less categorised groups.
Other two groups are not even having that much groups.
Hope helps ...
Cells don't grow very big because they have to be able to diffuse through material easily. Also, when cells are small and plentiful they are easy to replace when damaged.
