Progesterone levels are the highest in the middle of the luteal phase i.e at the eighth or ninth day of menstural cycle. it is the hormone which is released after ovulation. It is produced by the corpus luteum (an area created by the collapsed follicle) which consists of ovulated egg. At this stage the uterus lining gets thick and also estrogen is at high level. If the conception does not takes place the level of progesterone falls as the corpus luteum starts to break.
What happens at that point is that the lining sheds through the vagina otherwise known as the menstrual cycle which occurs if the egg has not been fertilized.
Cancer is unchecked cell growth. Mutations in genes can cause cancer by accelerating cell division rates or inhibiting normal controls on the system, such as cell cycle arrest or programmed cell death. As a mass of cancerous cells grows, it can develop into a tumor.