The genetic code is the set of rules by which information encoded within genetic material (DNA or mRNA sequences) is translated into protines by living cells
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A principle of law stating that within a sequence of undisturbed sedimentary rocks, that the oldest layers are on the bottom and the youngest are on the top. rock layers have a unique set of fossil animal and plant remains which can be used to determine the relative ages of rock layers.
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DNA polymerase is an enzyme that helps in the synthesis of new strands of DNA. It is found in both prokaryote and eukaryotes. In prokaryotes, there are 3 types of DNA polymerase and more DNA polymerase found in eukaryotes.
The 3 types of DNA polymerase are DNA polymerase I, DNA polymerase II, DNA polymerase III. The DNA pol I and DNA pol II helps in DNA repair rather than DNA replication. The DNA pol III is the major enzyme that initiates the replication.
DNA polymerase III is a multisubunit enzyme that functions as a dimer of these multiple subunits. The DNA polymerase enzyme has 3 significant enzymatic activities -
All DNA polymerase direct the synthesis of DNA from 3' to 5' end.
It possesses 3' to 5' exonuclease activity. It also helps in proofreading activity by replacing the incorrect nucleotides with the correct base sequence.
Some DNA polymerase has a 5' to 3' exonuclease activity. It is found in the lagging strand.
DNA polymerase is not able to initiate DNA synthesis alone. They need a free 3' end, where the enzyme can add new nucleotides. It means they require 2 primers to initiate the DNA replication in both the direction.
The strands act as complementary to the DNA polymerase. The DNA polymerase adds new strands continuously in 5' to 3' direction in the leading strand. While in lagging strand short fragments of DNA formed. Later they attached by DNA ligase.
DNA polymerase also needs RNA polymerase in some cases to start replication. Such a process is called reverse transcription.
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