Yes, it is true that Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia.
Focal malformations of cortical development, including focal cortical dysplasia (FCD) and hemimegalencephaly (HME), are important causes of intractable childhood epilepsy.
Using targeted and exome sequencing on DNA from resected brain samples and non-brain samples from 53 patients with FCD or HME, we identified pathogenic germline and mosaic mutations in multiple PI3K/AKT pathway genes in 9 patients, and a likely pathogenic variant in 1 additional patient.
Our data confirm the association of DEPDC5 with sporadic FCD but also implicate this gene for the first time in HME. Our findings suggest that modulation of the mammalian target of rapamycin pathway may hold promise for malformation-associated epilepsy.
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Answer:
but I don't see a quest in this question
Sedimentary rocks are the product of 1) weathering of preexisting rocks, 2) transport of the weathering products, 3) deposition of the material, followed by 4) compaction, and 5) cementation of the sediment to form a rock. The latter two steps are called lithification.
Explanation:
Incinerators are not helpful in reducing pollution as they produce a lot of ash and smoke so it increases the air pollution by burning of waste.
Solar and wind energy are the clean source of energies replacing the fuels. Catalytic converters reduce the air pollution from the exhaust fumes of vehicles.
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Out of the following choices given, the true statement about diffusion is molecules move from areas of high concentration to areas of low concentration. The correct answer will be D.
