Answer: DURING THE EMBRYONIC PERIOD.
Explanation: Teratogens are agents which can cause a birth defect. They are usually something in the environment that the mother may be exposed to during her pregnancy. Teratogens could be a prescribed medication, a street drug, alcohol use, or a disease present in the mother which has the tendency to increase the chance for the baby to be born with a birth defect. About 4 to 5 percent of birth defects are caused by exposure to a teratogen.
When a baby is developing, there are certain organs of the body forming at certain times.
If a teratogen has the potential to interfere with the closure of the neural tube, for example, the exposure to the teratogen must occur in the first 3.5 to 4.5 weeks of the pregnancy (Embryonic Stage), since this is when the neural tube is closing.
Most teratogens are harmful only during a critical window of development example thalidomide (cancer drug) is teratogenic only between days 28 and 50 of pregnancy.
Teratogenic agents inhibit specific receptors or enzymes or disrupt specific developmental pathways example some agents show neurotropism or cardiotropism.