Answer:
As a cell grows bigger, its internal volume enlarges and the cell membrane expands. Unfortunately, the volume increases more rapidly than does the surface area, and so the relative amount of surface area available to pass materials to a unit volume of the cell steadily decreases.
One advantage would be fertility
I believe the answer is Axis III
In psychiatric problem, the doctor could make diagnosis in 5 different axis to make sure they assess the patient comprehensively. Axis III is dedicated for general medical condition. In this case, serious cystic acne and bad skin would be categorized as general medical condition because it was not psychological or personality disorder.