The mutation resulting in sickle cell disease changes one base pair of DNA so that a codon now codes for a different amino acid, making it an example of a missense mutation. Missense mutation is the mutation characterized with <span>changes in one base pair so that the whole amino acid is changed.</span>
Being born with the genes, and evolving to reach food easier
Maybe, IDK Tbh XD
There are several ways;
The Skeletal system protects for example the heart and several aspects of large vasculature. The skeleton also has the means to produce blood cells in the marrow of some of the bones.
It's biproducts or by cutting it open and find out.