Answer:
Dust bowl resulted from extreme drying and loosening of the soil that resulted in soil erosion by wind. Thus, it can be related that poor agricultural practices like over plowing , over grazing and leaving the land barren are human activities that must have contributed to the dust bowl.
Explanation:
- Dust bowl is referred to a period in early twentieth century when the the American and Canadian prairies faced severe dust storms.
- These dust storms resulted from severe drought and failure of practices to prevent soil erosion.
- Several people and livestock died as a result of choking.
- Over plowing, removal of top soil and small grasses exposed the soil to eroding winds and caused the dust storms.
Answer:
The correct answer is - Archaea or archaebacteria.
Explanation:
Archaea is the domain and the kingdom of the single-cell prokaryotic organisms as they lack a nucleus. These organisms are present in extreme habitats such as hot springs, high saline water. These organisms can live in extremely aggressive environments which makes it a uniqe characteristic of this organism.
In the given condition the organism that lives in hypersaline water is most likely a member of the Archaea domain or Archaebacteria kingdom as it is found in the hypersaline waters of Southeastern Australia and unicellular organisms.
Answer:
For a full list of topics: A-Z Index ... We know that not all birth defects can be prevented. ... avoid harmful substances, choose a healthy lifestyle, and talk with your ... one month before and during pregnancy, it can help prevent major birth defects of ... planning a pregnancy, she should not stop taking medications she needs or .
Explanation:
Answer:
Exosomes as Therapeutic Target
Given the fact that elevated exosome levels are often correlated with greater severity of different types of cancer, reducing circulating exosomes to normal levels is one of therapeutic strategies to increase treatment efficacy. There are different approaches to modulate exosome production: 1) Inhibition of exosome formation: inhibit crucial proteins involved in exosome formation pathway; 2) Inhibition of exosome release: inhibit important regulators of exosome release process, increased intracellular Ca2+, change cellular microenvironmental pH; 3) Inhibition of exosome uptake: add proteinase for surface proteins on exosomes may serve as receptors for uptake pathways. In addition to control exosomes production, removal of exosomes from the entire circulatory system might be a novel strategy for cancer treatment.
Exosomes could also be used as cancer immunotherapy becasue tumor-derived exosomes carry antigens that is a great source of specific stimulus for the immune response against tumors. Both tumor-derived and dendritic cell-derived exosomes have showed capability to stimulate tumor antigen-specific responses in experimental animal models and human clinical trials.
Exosomes as Targeted Drug Delivery Vehicles
Exosomes became one of the most common methods applied in drug delivery system because of several advantages they have. Firstly, exosomes normally have a small size 40-100 nm, which is more homogenous compared to other microvesicles. This will lead them to evade rapid clearance by the mononuclear phagocyte and enhances passage through fenestrations in the vessel wall. Secondly, due to their endogenous origin, they are less toxic for and better tolerated by the immune system. It facilitates them to avoid causing side effects that normally occur with synthetic nanoparticles. Additionally, the specific ligand or protein expressed on the exosome surface increases efficiency of cargo into the cytosol of the target cell, and therefore fewer off-target effects. Exosomes are generally found most useful as a drug delivery medium in cancer therapy, anti-inflammation and gene interference therapy such as transferring of miRNA.
There are different kinds of cargos encapsulated by exosomes, especially like siRNA or miRNA. The delivery of RNA is attracting because they are rapid degradation in cell circulation and have the limitation in passing through the membrane and in cellular uptake. Chemotherapeutics loaded into exosomes is also used for cancer therapy such as doxorubicin. In principle, there are four key components to achieve correct functionality and efficacy during exosomes drug delivery:1) Choosing the donor cell type to produce drug-carrying exosomes; 2) Using correspond methods to encapsulate the exosomes cargo; 3) Enhancing the specificity of cargo delivery by targeting peptides on the surface of the exosomes; 4) Administrating exosomes to target the area of disease.
Explanation:
https://www.creative-biostructure.com/exosome-applications-652.htm
