The answer to this question is A) Biomass!
The right answer is D.
The absorption of molecules at the level of the skin is carried out by passive diffusion for the molecules of low molecular weight (lower than 400 Da), the skin being covered with a lipoprotein film rich in water by its stratum corneum, rendering it little-permeable.
This absorption may be variable according to factors related to the skin such as stratum corneum's thickness, the state of hydration, the presence of cutaneous lesions or individual variations.
External factors may also modulate percutaneous absorption such as contact time, iontophoresis or the presence of specific adjuvants.
Enzymes are regulated by more than the binding of small molecules. A second method that is used all the time by eucaryotic cells to regulate a protein's function is the covalent addition of a phosphate group to one of its amino acid side chains. These phosphorylation events can affect the protein in two important ways.
