food goes into the human digestive system through the mouth before then moving through the pharynx, then esophagus, then stomach,then intestines, rectum and anus.
Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
The formula for finding the kinetic energy of an object is:
KE = 0.5MV^2,
Where:
M= Mass
V = Speed
From the information given above,
M = 21 kg
V = 3 m/s
KE = 0.5 * 21 * 9 = 94.5
Therefore, the canoe's kinetic energy is 94.5 J
Open-mindedness is needed for the emerging scientific ideas to be accepted (or : to not be rejected without consideration).
Additionally, open-mindedness as a attitude often leads to new scientific ideas emerging: it means that people are more comfortable to try out new things and to test new hypotheses.
Having the haploid number of chromosomes allows the zygote to have the correct number. If gametes weren't haploid, every generation of organisms would have twice as many chromosomes as their parents. I hope my answer has come to your help. God bless and have a nice day ahead!
