The equation to find the slope of a line is . Y1 is 5, Y2 is 3, X1 is 2, and X2 is -4. Plug these numbers in to get the equation . 5-3 = 2. (-4)-2 = -6. This gives a slope of 2/-6, which can be reduced by dividing the numerator and denominator by 2 to get a final slope of -1/3.